Chronic pain gene identified

View previous topic View next topic Go down

Chronic pain gene identified

Post by Tee on Fri Sep 09, 2011 10:39 pm

September 8, 2011 By Sunanda Creagh, The Conversation

British researchers say they have identified the gene that controls chronic pain, opening the door to new drug therapies that block the chemical processes that cause chronic back pain, headaches or arthritis.

Chronic pain, defined as pain that is experienced most days of the week for at least three months, afflicts around 1 in 5 Australians. It commonly disrupts a sufferer’s ability to lead a normal life.

Now a team led by Professor Peter McNaughton, Head of the Department of Pharmacology at the University of Cambridge, has isolated a gene called HCN2 that produces a protein that causes chronic pain.

“Individuals suffering from neuropathic pain often have little or no respite because of the lack of effective medications. Our research lays the groundwork for the development of new drugs to treat chronic pain by blocking HCN2,” said Professor McNaughton.

His team conducted a series of experiments on mice genetically engineered to be born without the HCN2 gene. The researchers observed that these mice responded normally to normal acute pain (which is produced by a sudden injury) but that removing the HCN2 gene abolished neuropathic pain.

Being able to control chronic pain without affecting normal pain responses was crucial, he said.

“Many genes play a critical role in pain sensation, but in most cases interfering with them simply abolishes all pain, or even all sensation,” Professor McNaughton said.

“This finding could be very valuable clinically because normal pain sensation is essential for avoiding accidental damage.”


http://medicalxpress.com/news/2011-09-chronic-pain-geneidentified.html

_________________
I love you “Health is the greatest gift, contentment the greatest wealth, faithfulness the best relationship.” Buddha[/color][/i]
avatar
Tee
Admin

Posts : 1887
Join date : 2011-04-14
Age : 47
Location : Whitstable, Kent

http://migrainetalk.forumotion.co.uk

Back to top Go down

View previous topic View next topic Back to top


 
Permissions in this forum:
You cannot reply to topics in this forum